Vitamin a may be indispensable for skin cancer shelter. The skin and mucosal cells are (cells that line the airways, digestive tract, and urinary tract) function as a barrier and form the body’s initial line of defense against infection.
Retinol (vitamin a) and its metabolites (e. G. Beta carotene which is converted to vitamin a) are needed to maintain the integrity and function of these cells. (proceedings of the nutrition society. 1999).
In 1999 group of researchers from the univ. of michigan reported that UV(ultraviolet) radiation from the sun causes a major loss of retinoic acid receptors in skin cells.
They came to conclusion that UV(ultraviolet) radiation causes a vitamin a deficiency that may have destructive effects on skin function, contributing to premature aging of the skin and the creation of skin cancer. (nature medicine 1999; 5(4): 418-422).
In 2001 group of researchers from the univ. of texas, baylor college of medicine science and the univ. of arizona viewed at the effects of direct sun exposure and retinoic acid (vitamin a) receptors in skin cells. The study examined these effects in relevance to squamous skin carcinogenesis (scc) (the process by which normal cells are transformed into cancer cells). They observed a progressive reduction in retinoic acid (vitamin a) receptors from a normal skin to pre-cancerous skin developing to invasive skin scc (squamous cell carcinogenesis).
Their conclusion indicated that the suppression of a retinoid (vitamin A) receptors occurs early in the precancerous stage and is associated with advancement of squamous skin carcinogenesis (the creation of cancer). (cancer res, 61: 4306-10, 2001).
Some Researchers from Swiden(Swedish), reported in the journal experimental dermatology(skin Study) in 2003, utilized cultured normal humane keratinocytes and melanocytes (skin cells) to study the effects of uv irradiation on the main retinoid receptors in the humane skin. In 1993 edes and a colleague at the harry s.
Truman memorial’s veterans hospital, columbia, missouri, reported that in a review that exposure to benzopyrene, a carcinogen (cancer causing substance) causes vitamin a depletion in exposed tissues. They mentioned that the result is obvious while on a vitamin a enough diet but significantly, without a decline in serum (blood) vitamin a.
In Simple other words, benzopyrene depleted vitamin a even when the diet was adequate in the vitamin, and this depletion is not obvious in blood tests.
